Review Article

Hepatitis C Virus Infection: Looking for Interferon Free Regimens

Table 3

Clinical trials ongoing using IFN-free regimens.

DrugsDAATrialGenotypesPatientsSponsor

Faldaprevir + BI207127 + RibavirinPI NS3/4A + NNPI NS5BPhase 31Treatment-naive Boehringer Ingelheim
Simeprevir + TMC647055 + Ritonavir + RibavirinPI NS3/4A + Ritonavir potentiated
NNPI NS5B
Phase 2a 1Treatment-naive and previous relapsersJanssen R & D
Simeprevir + Sofosbuvir + RibavirinPI NS3/4A + NPI NS5BPhase 2a1Null respondersJanssen R & D
Asunaprevir + DaclatasvirPI NS3 + NS5A inhibitorPhase 31bTreatment-naiveBristol-Myers Squibb
ABT450 + Ritonavir + ABT267Ritonavir potentiated PI NS3 + NS5A inhibitorPhase 21b, 2Treatment-experiencedAbbVie (prior sponsor, Abbott)
ABT450 + Ritonavir + ABT267 + ABT333Ritonavir potentiated PI NS3 + NS5A inhibitor + NNPI NS5BPhase 21Treatment-experiencedAbbott
Danoprevir + Ritonavir + Mericitabine + RibavirinRitonavir potentiated PI NS3/4A + NPI NS5BPhase 21Treatment-experiencedHoffmann-La Roche
Sofosbuvir + GS5885 + RibavirinNPI NS5B + NS5A inhibitorPhase 31Treatment-experiencedGilead Sciences
Sofosbuvir + RibavirinNPI NS5BPhase 32, 3Treatment-naive and Treatment-experiencedGilead Sciences
Setrobuvir + Danoprevir + Ritonavir + MericitabineNNPI NS5B + Ritonavir potentiated PI NS3/4A + NPI NS5BPhase 21Treatment-naive and null respondersHoffmann-La Roche
Asunaprevir + Daclatasvir + BMS791325 PI NS3 + NS5A inhibitor + NNPI NS5BPhase 21Treatment-naiveBristol-Myers Squibb
Daclatasvir + Sofosbuvir + RibavirinNS5A inhibitor + NPI NS5BPhase 21, 2, 3Treatment-naiveBristol-Myers Squibb
GS5885 + GS9451 + Tegobuvir + RibavirinNS5A inhibitor + PI NS3/4A + NNPI NS5BPhase 21Interferon ineligible or intolerant subjectsGilead Sciences

DAA: direct acting antiviral; NNPI: nonnucleoside polymerase inhibitor; NPI: nucleoside polymerase inhibitor; PI: protease inhibitor.