The Scientific World Journal

Review Article

Bisphophonates in CKD Patients with Low Bone Mineral Density

Table 2

Two classes of bisphosphonates.
BisphosphonatesAgentsR1 side chainR2 side chain
NonnitrogenousEtidronate 837573.tab.002a837573.tab.002d
Clodronate 837573.tab.002b837573.tab.002b
Tiludronate 837573.tab.002c837573.tab.002e
NitrogenousPamidronate 837573.tab.002a837573.tab.002f
Neridronate837573.tab.002a837573.tab.002g
Olpadronate837573.tab.002a837573.tab.002h
Alendronate 837573.tab.002a837573.tab.002i
Ibandronate837573.tab.002a837573.tab.002j
Risedronate 837573.tab.002a837573.tab.002k
Zoledronate837573.tab.002a837573.tab.002l
The bisphosphonates are analogous to that of the naturally occurring pyrophosphates, with two-side chains (R1 and R2) attached to the carbon core. The R1 side chain determines bone-binding affinity, and the R2 side chain determines interception potency.