Research Article
Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China
Table 2
Genotype and allele frequency of 4 sites of
NOS1 gene
.
| | Genotype | Controls (%) | Patients (%) | OR (95% CI) | | Adjusted OR (95% CI) | |
| | rs1483757 | | | | | | | | AA | 93 (22.5) | 88 (18.4) | 1.00 | — | 1.00 | — | | AG | 211 (51.1) | 251 (52.6) | 0.80 (0.56–1.12) | 0.193 | 0.81 (0.56–1.19) | 0.284 | | GG | 109 (26.4) | 138 (28.9) | 0.75 (0.51–1.10)
| 0.138
| 0.74 (0.48–1.12) | 0.737
| | A allele | 397 (48.1) | 427 (44.8) | 1.00 | — | | | | G allele | 429 (51.9) | 527 (55.2) | 1.14 (0.95–1.38) | 0.163 | | | | rs2139733 | | | | | | | | AA | 80 (19.4) | 83 (17.4) | 1.00 | — | 1.00 | — | | AT | 207 (50.1) | 252 (52.8) | 0.85 (0.60–1.22) | 0.381 | 0.87 (0.59–1.29) | 0.484 | | TT | 126 (30.5) | 142 (29.8) | 0.92 (0.62–1.36)
| 0.677
| 0.92 (0.60–1.42)
| 0.714
| | A allele | 367 (81.3) | 418 (84.9) | 1.00 | — | | | | T allele | 459 (18.7) | 536 (15.1) | 0.99 (0.77–1.29) | 0.960 | | | | rs2293050 | | | | | | | | CC | 130 (31.5) | 143 (30.0) | 1.00 | — | 1.00 | — | | CT | 203 (49.2) | 252 (52.8) | 0.89 (0.66–1.20) | 0.431 | 0.86 (0.64–1.23) | 0.885 | | TT | 80 (19.4) | 82 (17.2) | 1.07 (0.73–1.58) | 0.722 | 1.07 (0.70–1.64) | 0.764 | | C allele | 463 (56.1) | 538 (56.4) | 1.00 | — | | | | T allele | 363 (43.9) | 416 (43.6) | 1.05 (0.81–1.36) | 0.734 | | | | rs7308402 | | | | | | | | GG | 386 (93.5) | 427 (89.5) | 1.00 | — | 1.00 | — | | AG | 27 (6.5) | 50 (10.5) | 0.60 (0.37–0.97) | 0.038 | 0.57 (0.34–0.98) | 0.041 | | AA | — | — | — | — | — | — | | G allele | 799 (96.7) | 904 (94.8) | 1.00 | — | | | | A allele | 386 (3.3) | 434 (5.2) | 0.61 (0.38–0.99) | 0.041 | | |
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Adjusting gender, age, hypertension, diabetes, smoking, drinking, serum LDL-C, and blood glucose.
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