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The Scientific World Journal
Volume 2013 (2013), Article ID 901215, 5 pages
Increased Risk of Atrial and Ventricular Arrhythmia in Long-Lasting Psoriasis Patients
1Cardiology Department, Faculty of Medicine, Yuzunci Yil University, 65200 Van, Turkey
2Van High Edücation and Research Hospital, 65100 Van, Turkey
3Dermatology Department, Faculty of Medicine, Yuzunci Yil University, 65200 Van, Turkey
4Cardiology Department, Hisar Intercontinental Hospital, 34768 Istanbul, Turkey
Received 25 January 2013; Accepted 3 March 2013
Academic Editors: C. Carbucicchio, H. Kitabata, A. N. Makaryus, C. Spaulding, and G. Stabile
Copyright © 2013 Hakki Simsek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background. Several reports have demonstrated an association between psoriasis and cardiovascular diseases. P wave dispersion (PWD) is the most important electrocardiographic (ECG) markers used to evaluate the risk of atrial arrhythmias. QT dispersion (QTD) can be used to assess homogeneity of cardiac repolarization and may be a risk for ventricular arrhythmias. Aim. To search PWD and QTD in patients with psoriasis. Methods. Ninety-four outpatient psoriasis patients and 51 healthy people were evaluated by physical examination, 12-lead ECG, and transthoracic echocardiography. Severity of the psoriasis was evaluated by psoriasis area and severity index (PASI). Results. Mean disease duration was (range, 3–360) months and PASI ranged from 0 to 34.0 (mean ± SD; ). Compared to control group, psoriatic patients had significantly shorter Pmax and Pmin durations, longer QTcmax, and greater PWD and QTcD. Transmitral deceleration time (DT) and isovolumetric relaxation time (IVRT) were significantly longer among psoriasis patients. QTcD and PWD were significantly correlated with disease duration (, , and , , resp.). Conclusions. In this study, we found that both PWD and QTcD are increased in psoriasis patients compared to healthy subjects. In addition, they had longer DT and IVRT.
Psoriasis is one of the most prevalent T cell-mediated chronic inflammatory disease affecting around 1–3% of human population worldwide . Cardiovascular abnormalities like arterial hypertension, arterial atherosclerosis, and heart valve abnormalities are frequently observed in the course of this disease [2–5]. Although the pathogenesis of psoriasis is still not fully understood, psoriasis is associated with markers of systemic inflammation, such as increased C-reactive protein levels  and T-helper cell type 1 (TH1) cytokines , and inflammatory processes and oxidative stress are frequently delineated [8, 9]. Rhythm and conduction disturbances and sudden cardiac death are important manifestations of cardiac involvement in autoimmune rheumatic diseases with increased inflammation. However, there is scarcity of data on rhythm abnormalities and conduction disturbances in psoriatic patients.
P wave dispersion (PWD) is an electrocardiographic marker that has been associated with inhomogeneous and discontinuous propagation of sinus impulses [10, 11]. Prolonged P wave duration and increased PWD have been reported to carry an increased risk for AF [11, 12]. Recent studies have also demonstrated the possible implication of inflammation and oxidative stress in pathogenesis of AF [13–15].
QT dispersion (QTd) can be used to assess the homogeneity of cardiac repolarization and autonomic function . Increased heterogeneity of repolarization has been associated with increased risk of ventricular tachyarrhythmias . Kowalewski et al.  showed that levels of proinflammatory cytokines are increased in young people with ventricular arrhythmias having no evidence of myocardial injury suggesting an inflammatory background for ventricular arrhythmias.
Although there is no direct evidence for an association between psoriasis and AF or ventricular arrhythmias, we assume that systemic inflammation in patients with psoriasis might contribute to the development of arrhythmia.
To the best of our knowledge, PWD and QTD in psoriasis have not been searched in the literature. In this study, we evaluated PWD and QTD in patients with psoriasis without overt cardiac involvement.
Ninety-four outpatient psoriasis patients and 51 healthy people were included in the study. Patients having systemic hypertension, diabetes mellitus, history of ischemic heart disease, significant valvular heart disease, chronic obstructive pulmonary disease, hypo- or hyperthyroidism, renal failure or any associated systemic disease were excluded. Diagnosis of psoriasis was confirmed by dermatological examination and/or punch biopsy. Severity of the psoriasis was evaluated by psoriasis area and severity index (PASI). Patients were evaluated by physical examination, 12-lead electrocardiography, and transthoracic echocardiography. The study was approved by the Yuzuncu Yil University, Faculty of Medicine Ethics Committee in accordance with Declaration of Helsinki. All participants were informed about the study and their consents were obtained.
Twelve-lead ECGs were obtained after a 10-minute rest, with 20 mm/mV amplitude and 50 mm/s rate with standard lead positions between 13:00 and 16:00 o’clock using a commercially available machine (Marquatte Case, Hellige Medical System, Cardiosmart, Hellige Instrument Company, Freiburg, Germany). ECGs were manually measured by the use of a magnifying glass by two blinded cardiologists having no information about the patients. The beginning of the P wave was defined as the point where the initial deflection of the P wave crossed the isoelectric line, and the end of the P wave was defined as the point where the final deflection of the P wave crossed the isoelectric line. The difference between maximum and minimum P wave durations was defined as PWD. QT intervals were taken beginning from the onset of the QRS complex to the end of the T wave, which was defined as its return to the TP baseline. If U waves were present, the QT interval was measured to the nadir of the curve between the T and U waves. The R-R interval was measured and used to compute the heart rate and to correct QT interval (QTc) with Bazett’s formula. QTc dispersion (QTcD) was determined as the difference between the maximum and minimum QTc intervals in different leads. No patient had less than nine measurable leads. The intraobserver and interobserver variations for PWD and QTcD were less than 5%.
All the study population underwent a transthoracic examination. Using M-mode echocardiography, long-axis measurements were obtained at the level distal to the mitral valve leaflets according to the recommendations of the American Society of Echocardiography. Pulse wave Doppler measurements of aortic and transmitral valve flow profiles were obtained. The transmitral flow velocity was measured using pulse wave Doppler with the sample volume positioned between the mitral leaflet tips during diastole. Early diastolic flow, atrial contraction signal, early diastolic flow/atrial contraction signal (E/A), and deceleration time (DT) were measured. Isovolumetric relaxation time (IVRT) was determined as the interval between the end of the aortic outflow and the start of the mitral inflow signal. Values were measured on three separate beats and then averaged for all parameters. Pulmonary artery systolic pressure (PASP) was calculated from tricuspid insufficiency flow in the parasternal short axis and apical four-chamber view, and the highest tricuspid regurgitation velocity was taken as a study sample. Estimated PASP above 30 mmHg was an exclusion criteria.
Results are expressed as mean ± SD. Using an SPSS package 18.0, data between the groups were compared with Student’s -test for continuous variables, chi-square test for qualitative variables, and Mann-Whitney -test for variables without normal distribution. Pearson correlation analysis was used to assess the correlation between variables. A two-tailed value <0.05 was considered significant.
Mean disease duration was 129,4 ± 83,9 (range, 3–360) months, and PASI ranged from 0 to 34,0 (mean ± SD; 7,6 ± 6,7). Seventy-seven patients (81,9%) had plaque type, 8 (8,5%) patients had palmoplantar type, and 9 (9,6%) patients had pustular type psoriasis. There were no significant differences between psoriasis patients and control subjects in respect to age, gender, body mass index, blood pressures, smoking, and lipid profiles (Table 1). Of the diastolic function parameters, DT and IVRT were significantly longer among psoriasis patients. However, frequency of diastolic dysfunction was not significantly increased (Table 1). Compared to control group, psoriatic patients had significantly shorter Pmax and Pmin durations, longer QTcmax, and greater PWD and QTcD (Table 2, Figure 1). QTcD and PWD were significantly correlated with disease duration (, , and , , resp.) but not with any other clinical or echocardiographic parameter. In addition DT and IVRT were significantly correlated with age (, , and , , resp.). There were no significant correlations between PASI and PWD and QTcD.
In this study, we found that both PWD and QTcD are increased in psoriasis patients compared to healthy subjects. In addition, they had longer DT and IVRT.
Several studies have demonstrated that cardiovascular diseases and their associated risk factors like hypertension, diabetes, hyperlipidemia, obesity, and smoking are more common in patients with psoriasis than in the general population [19, 20]. Intrinsic associated risks and/or psychological impact of psoriasis driving risky behaviors such as obesity and smoking may increase cardiovascular risk [21, 22].
However, there is scarcity of data on rhythm abnormalities and conduction disturbances in psoriatic patients, despite a quite clear connection between arrhythmia occurrence and chronic inflammatory processes [23, 24].
Systemic inflammatory response and oxidative stress are the most important mechanisms in the development of psoriasis [2, 3]. Furthermore, recent studies have also demonstrated an inflammatory background of ventricular arrhythmias and the possible implication of inflammation and oxidative stress in pathogenesis of AF [13–15, 18].
P-wave duration and P wave dispersion are the most important ECG markers used to evaluate the risk of atrial arrhythmias . Several studies showed that PWD has a predictive value for AF in patients with various conditions [26, 27]. Various studies have demonstrated that increased QT interval and QT dispersion may increase the incidence of sudden death and ventricular tachycardia in many cardiovascular conditions and noncardiac diseases. It has been shown that PWD and QT interval and QT dispersion were increased in autoimmune diseases such as rheumatoid arthritis, SLE, and systemic sclerosis [28–31].
Inflammation associated with psoriasis may have an effect on increased PWD and QTcD. However, lack of measurement of inflammatory markers in our study limits this conclusion. Despite many shortcomings, PASI is still the most commonly used score for the assessment of severity of psoriasis . Severity of the disease may reflect intensity of inflammation and therefore may be associated with PASI. Lack of significant correlation between PWD and QTcD with PASI may be due to relatively low PASI levels in our study population.
P wave dispersion and QTD have been shown to be increased in LV diastolic dysfunction [33, 34]. It has been reported that psoriasis may accompany mild diastolic dysfunction . Although we could not find a significant association between frequency of diastolic function and PWD and QTcD, still there may be a possible contribution of diastolic dysfunction parameters to the increased PWD in psoriasis.
Increased sympathetic activity may be another possible mechanism for increased PWD and QTcD in psoriasis. Sympathetic activity has been linked to PWD and QT-dispersion [36, 37]. Compared with control subjects, psoriasis patients displayed a blunted increase in heart rate and a sharper increase in diastolic blood pressure during stress examination .
Small number of study patients and lack of long-term clinical followup are the major limitations of our study. Another important limitation is lack of measurements of markers for inflammation. Automated ECG measurements were not available and manual calculation of P wave and QT measurements may be criticized. Whether increased PWD and QTcD in patients with psoriasis predicts poorer clinical outcomes or mandates any special treatments warrants further study.
P wave dispersion and QTcD are increased in psoriasis patients and correlated with disease duration. In addition PWD correlated with diastolic function parameters of IVRT and DT. Our findings suggest that increased PWD and QTd are potentially useful, simple, and noninvasive methods for the early detection of subclinical cardiac involvement in patients with especially long-lasting psoriasis. We suggest that long-lasting psoriasis patients may be considered for referral for cardiovascular evaluation. Larger and longer-term studies are necessary to evaluate clinical implications of our findings.
Conflict of Interests
There is no conflict of interests. The authors state that they do not have a financial relation with the machine mentioned in the paper (Marquatte Case, Hellige Medical System, Cardiosmart, Hellige Instrument Company, Freiburg, Germany) nor any other conflict of interests.
- E. M. Farber and M. L. Nall, “The natural history of psoriasis in 5,600 patients,” Dermatologica, vol. 148, no. 1, pp. 1–18, 1974.
- L. Torok, E. Toth, and A. Bruncsak, “Correlation between psoriasis and cardiovascular diseases,” Zeitschrift fur Hautkrankheiten, vol. 57, no. 10, pp. 734–739, 1982.
- T. Henseler and E. Christophers, “Disease concomitance in psoriasis,” Journal of the American Academy of Dermatology, vol. 32, no. 6, pp. 982–986, 1995.
- J. L. Moya, M. Sanchez, M. D. Morales, and E. Brito, “Mitral valve prolapse (MVP) in psoriatic arthritis (PA),” Archives of Internal Medicine, vol. 147, no. 5, p. 992, 1987.
- W. F. Muna, D. H. Roller, J. Craft, R. K. Shaw, and A. M. Ross, “Psoriatic arthritis and aortic regurgitation,” Journal of the American Medical Association, vol. 244, no. 4, pp. 363–365, 1980.
- G. Chodorowska, D. Wojnowska, and M. Juszkiewicz-Borowiec, “C-reactive protein and α2-macroglobulin plasma activity in medium-severe and severe psoriasis,” Journal of the European Academy of Dermatology and Venereology, vol. 18, no. 2, pp. 180–183, 2004.
- J. G. Krueger and A. Bowcock, “Psoriasis pathophysiology: current concepts of pathogenesis,” Annals of the Rheumatic Diseases, vol. 64, no. 2, pp. ii30–ii36, 2005.
- V. E. Friedewald Jr., J. C. Cather, K. B. Gordon, A. Kavanaugh, P. M. Ridker, and W. C. Roberts, “The editor's roundtable: psoriasis, inflammation, and coronary artery disease,” The American Journal of Cardiology, vol. 101, no. 8, pp. 1119–1126, 2008.
- H. M. Kremers, M. T. McEvoy, F. J. Dann, and S. E. Gabriel, “Heart disease in psoriasis,” Journal of the American Academy of Dermatology, vol. 57, no. 2, pp. 347–354, 2007.
- P. E. Dilaveris, E. J. Gialafos, G. K. Andrikopoulos et al., “Clinical and electrocardiographic predictors of recurrent atrial fibrillation,” Pacing and Clinical Electrophysiology, vol. 23, no. 3, pp. 352–358, 2000.
- P. E. Dilaveris, E. J. Gialafos, S. K. Sideris et al., “Simple electrocardiographic markers for the prediction of paroxysmal idiopathic atrial fibrillation,” The American Heart Journal, vol. 135, no. 5 I, pp. 733–738, 1998.
- N. Ozer, K. Aytemir, E. Atalar et al., “P wave dispersion in hypertensive patients with paroxysmal atrial fibrillation,” Pacing and Clinical Electrophysiology, vol. 23, no. 11, pp. 1109–1112, 2000.
- T. Liu and G. Li, “Is atrial fibrillation an inflammatory disease?” Medical Hypotheses, vol. 64, pp. 1237–1238, 2005.
- T. Liu, G. Li, L. Li, and P. Korantzopoulos, “Association between C-reactive protein and recurrence of atrial fibrillation after successful electrical cardioversion: a meta-analysis,” Journal of the American College of Cardiology, vol. 49, no. 15, pp. 1642–1648, 2007.
- P. Korantzopoulos, T. M. Kolettis, D. Galaris, and J. A. Goudevenos, “The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation,” International Journal of Cardiology, vol. 115, no. 2, pp. 135–143, 2007.
- J. Kautzner and M. Malik, “QT interval dispersion and its clinical utility,” Pacing and Clinical Electrophysiology, vol. 20, no. 10, pp. 2625–2640, 1997.
- M. Zabel, S. Portnoy, and M. R. Franz, “Electrocardiographic indexes of dispersion of ventricular repolarization: an isolated heart validation study,” Journal of the American College of Cardiology, vol. 25, no. 3, pp. 746–752, 1995.
- M. Kowalewski, M. Urban, B. Mroczko, and M. Szmitkowski, “Proinflammatory cytokines (IL-6, TNF-alpha) and cardiac troponin I (cTnI) in serum of young people with ventricular arrhythmias,” Polskie Archiwum Medycyny Wewnetrznej, vol. 108, no. 1, pp. 647–651, 2002.
- A. B. Kimball, D. Robinson, Y. Wu et al., “Cardiovascular disease and risk factors among psoriasis patients in two US healthcare databases, 2001-2002,” Dermatology, vol. 217, no. 1, pp. 27–37, 2008.
- A. L. Neimann, D. B. Shin, X. Wang, D. J. Margolis, A. B. Troxel, and J. M. Gelfand, “Prevalence of cardiovascular risk factors in patients with psoriasis,” Journal of the American Academy of Dermatology, vol. 55, no. 5, pp. 829–835, 2006.
- J. Shapiro, A. D. Cohen, M. David et al., “The association between psoriasis, diabetes mellitus, and atherosclerosis in Israel: a case-control study,” Journal of the American Academy of Dermatology, vol. 56, no. 4, pp. 629–634, 2007.
- A. B. Kimball, C. Jacobson, S. Weiss, M. G. Vreeland, and Y. Wu, “The psychosocial burden of psoriasis,” The American Journal of Clinical Dermatology, vol. 6, no. 6, pp. 383–392, 2005.
- R. M. Klein, E. G. Vester, M. U. Brehm et al., “Inflammation of the myocardium as a trigger for arrhythmias,” Zeitschrift fur Kardiologie, vol. 89, no. 3, pp. III24–III35, 2000.
- A. Sajadieha, O. W. Nielsen, V. Rasmussen, H. O. Hein, S. Abedini, and J. F. Hansen, “Increased heart rate and reduced heart-rate variability are associated with subclinical inflammation in middle-aged and elderly subjects with no apparent heart disease,” European Heart Journal, vol. 25, no. 5, pp. 363–370, 2004.
- O. Turgut, I. Tandogan, M. B. Yilmaz, K. Yalta, and O. Aydin, “Association of P wave duration and dispersion with the risk for atrial fibrillation: practical considerations in the setting of coronary artery disease,” International Journal of Cardiology, vol. 144, no. 2, pp. 322–324, 2010.
- P. E. Dilaveris and C. I. Stefanadis, “P wave dispersion. A valuable non-invasive marker of vulnerability to atrial arrhythmias,” Hospital Chronicles, vol. 1, pp. 130–137, 2006.
- A. Michelucci, G. Bagliani, A. Colella et al., “P wave assessment: state of the art update,” Cardiac Electrophysiology Review, vol. 6, no. 3, pp. 215–220, 2002.
- M. Yavuzkir, A. Ozturk, N. Dagli et al., “Effect of ongoing inflammation in rheumatoid arthritis on P-wave dispersion,” Journal of International Medical Research, vol. 35, no. 6, pp. 796–802, 2007.
- O. Dogdu, M. Yarlioglues, M. G. Kaya et al., “Assessment of atrial conduction time in patients with systemic lupus erythematosus,” Journal of Investigative Medicine, vol. 59, no. 2, pp. 281–286, 2011.
- A. Sgreccia, S. Morelli, L. Ferrante et al., “QT interval and QT dispersion in systemic sclerosis (scleroderma),” Journal of Internal Medicine, vol. 243, no. 2, pp. 127–132, 1998.
- A. Cindas, Y. Gökçe-Kutsal, L. Tokgözoglu, and A. Karanfil, “QT dispersion and cardiac involvement in patients with rheumatoid arthritis,” Scandinavian Journal of Rheumatology, vol. 31, no. 1, pp. 22–26, 2002.
- J. Schmitt and G. Wozel, “The psoriasis area and severity index is the adequate criterion to define severity in chronic plaque-type psoriasis,” Dermatology, vol. 210, no. 3, pp. 179–181, 2005.
- H. Gunduz, E. Binak, H. Arinc et al., “The relationship between P wave dispersion and diastolic dysfunction,” Texas Heart Institute Journal, vol. 32, no. 2, pp. 163–167, 2005.
- H. Gunduz, R. Akdemir, E. Binak, A. Tamer, and C. Uyan, “Relation between stage of left ventricular diastolic dysfunction and QT dispersion,” Acta Cardiologica, vol. 58, no. 4, pp. 303–308, 2003.
- H. Saricaoglu, S. Gullulu, E. Bulbul, J. Cordan, and S. Tunali, “Echocardiographic findings in subjects with psoriatic arthropathy,” Journal of the European Academy of Dermatology and Venereology, vol. 17, no. 4, pp. 414–417, 2003.
- A. N. Cheema, M. W. Ahmed, A. H. Kadish, and J. J. Goldberger, “Effects of autonomic stimulation and blockade on signal-averaged P wave duration,” Journal of the American College of Cardiology, vol. 26, no. 2, pp. 497–502, 1995.
- R. Marfella, P. Gualdiero, M. Siniscalchi et al., “Morning blood pressure peak, QT intervals, and sympathetic activity in hypertensive patients,” Hypertension, vol. 41, no. 2, pp. 237–243, 2003.
- M. Mastrolonardo, A. Picardi, D. Alicino, A. Bellomo, and P. Pasquini, “Cardiovascular reactivity to experimental stress in psoriasis: a controlled investigation,” Acta Dermato-Venereologica, vol. 86, no. 4, pp. 340–344, 2006.