The Scientific World Journal / 2013 / Article / Tab 2 / Clinical Study
A Real-World, Multicenter Assessment of Drugs Requiring Weight-Based Calculations in Overweight, Adult Critically Ill Patients Table 2 Dosing results for heparin by weight category compared to recommendations in the literature.
Drugs Weight category Patients evaluated Doses Average dose Median dose Minimum Maximum Literature dose recommendation [17 , 18 ] Underweight 0 0 — — — — VTE 80 units/kg then 18 units/kg/hr Maximum bolus 10,000 units Maximum initial rate 1600 units/hr
ASC 60 units/kg then 12 units/kg/hr Maximum bolus 5000 units. Max initial rate 1000 u/hr
Normal weight 11 52 17.61 17.41 9.29 26.00 Heparin (units/kg/hr) Overweight 17 39 12.23 11.97 6.00 18.00 Obese 9 34 12.87 11.67 3.93 22.00 Extremely obese 6 37 11.77 10.00 4.50 21.80