A Real-World, Multicenter Assessment of Drugs Requiring Weight-Based Calculations in Overweight, Adult Critically Ill Patients

Table 4

Adverse drug reactions reported.

Drug	ADR (𝑛=14 ADRs in 9 patients)	Weight category	Dosage	Weight-based dosage
Midazolam	Slightly responsive to noxious stimuli	Overweight	685.00 mcg/min	5.00 mcg/kg/min
Midazolam	Unresponsive to noxious stimuli	Overweight	2740.00 mcg/min	20.00 mcg/kg/min
Dobutamine	Ventricular tachycardia/implantable cardioverter-defibrillator firing	Underweight	386.77 mcg/min	5.00 mcg/kg/min
Dobutamine	Sinus tachycardia/implantable cardioverter-defibrillator fired	Morbidly obese	805.33 mcg/min	5.00 mcg/kg/min
Heparin	Bleeding	Normal weight	876.00 units/hr	11.20 units/kg/hr
Heparin	aPTT > 200	Overweight	3000.00 units/hr	25 units/kg/hr
Heparin	Bleeding	Obese	1150.00 units/hr	7.67 units/kg/hr
Heparin	Bleeding	Obese	1150.00 units/hr	7.67 units/kg/hr
Heparin	Bleeding	Overweight	2200.00 units/hr	18.33 units/kg/hr
Norepinephrine	Sinus bradycardia	Overweight	2.00 mcg/min	0.01 mcg/kg/min
Rocuronium	Peripheral nerve stimulation = 0	Overweight	27.33 mcg/min	0.20 mcg/kg/min
Rocuronium	Peripheral nerve stimulation = 0	Overweight	18.33 mcg/min	0.13 mcg/kg/min
Rocuronium	Peripheral nerve stimulation = 0	Overweight	16.00 mcg/min	0.12 mcg/kg/min
Rocuronium	Peripheral nerve stimulation = 0	Overweight	22.83 mcg/min	0.17 mcg/kg/min