Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma

Table 1

Synthetic MMP-9 inhibitors.

Name	Type of drug	Specifity of the inhibition	Reference
Batimastat	Peptidomimetic	MMP-1, -2, -3, -7, -9	[40]
Marimastat	Peptidomimetic	Broad spectrum	[41]
CTTHWGFTLC	Peptidomimetic	MMP-2, -9	[38]
CGYGRFSPPC	Peptidomimetic	MMP-2, -9	[42]
CRVYGPYLLC	Peptidomimetic	MMP-2, -9	[42]
ABT-518	Peptidomimetic	MMP-2, -9	[43]
GRENYHGCTTHWGFTLC	Peptidomimetic	MMP-2, -9	[39]
Ilomastat	Peptidomimetic	Broad spectrum	[44]
Tanovastat	Nonpeptidomimetic	MMP-2, -3, -9	[45]
Prinovastat	Nonpeptidomimetic	MMP-2, -3, -7, -9, -13	[46]
BMS-275291	Nonpeptidomimetic	MMP-2, -9	[47]
Metastat (COL-3)	Chemically modified tetracycline	MMP-1, -2, -8, -9, -13	[48]
CMT-3	Chemically modified tetracycline	MMP-8, -9, -MT1-MMP	[49]
Doxycycline	Chemically modified tetracycline	MMP-1, -2, -3, -8, -9, -10, -13	[50]
SB-3CT	Reform proenzyme structure	MMP-2, -9	[51]
Bisphosphonates	Analogues of inorganic pyrophosphate	MMP-1, -2, -7, -9, MT1-, MT2-MMP	[52]
Chlorhexidine	Bisbiguanide antiseptic	MMP-2, -8, -9	[53]
Letrozole	Nonsteroidal inhibitor of aromatase	MMP-2, -9	[54]
PCK 3145	Synthetic peptide based on PSP94	MMP-9	[55]