MicroRNAs in Hepatocellular Carcinoma: Regulation, Function, and Clinical Implications

Table 3

Clinical relevance of deregulated microRNAs in HCC.

miRNA	Expression in HCC	Clinical relevance
miR-122 [179]	Down	Poor prognosis
miR-124 [173]	Down	More aggressive and/or poor prognosis
miR-139 [107]	Down	Poor prognosis
miR-145 [110]	Down	Shorter disease-free survival
miR-199b [180]	Down	Poorer overall survival, and progression-free survival rates
miR-22 [181]	Down	Poor survival
miR-26 [182]	Down	Shorter overall survival
miR-29 [69]	Down	Worse disease-free survival
miR-99a [183]	Down	Shorter survival
let-7g [95]	Down	Poor survival
miR-10b [129]	Up	Poor prognosis
miR-125b [184]	Up	Good survival
miR-135a [131]	Up	Poor prognosis
miR-17-5p [185]	Up	Worse Edmondson-Steiner grade, vein invasion, shortened overall survival and disease-free survival
serum miR-17-5p [186]	Up	Poor prognosis
miR-155 [187]	Up	Poorer recurrence-free survival and overall survival
miR-182 [135]	Up	Intrahepatic metastasis and poor prognosis
C19MC miRNA [177]	Up	Increased risk of tumor recurrence and shorter overall survival time
miR-21 [188]	Up	Poor prognosis
miR-221 [188]	Up	Poor prognosis
miR-222 [178]	Up	Shorter disease-free survival
20-miRNA signature [189]	Up/down	Metastases and recurrence
19-miRNA signature [190]	Down	Poor survival