A Facile Synthesis of N-H- and N-Substituted Acridine-1,8-diones under Sonic Condition

Table 1

Comparison between CAN catalysed silent and sonic reactions.

Entry	Reactions	Silent condition^a		Sonic condition^b
		Time	Yield^c	Time	Yield^c
1	Dimedone (1 mmol) and 2-chloro-4-fluoroaniline (1 mmol) to form 5	45 min	75%	20 min	95%
2	Reaction between intermediates 5 and 6 to give product 4	4 h	50%	1 h	90%
3	Mixing all the reactants (1, 2, and 3)	5 h	50%	1 h	90%

aIn acetonitrile (3–5 mL) at 70°C. ^bIn a sonic bath at 26°C (35 kHz). ^cIsolated yields.