Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells

<table>Growth inhibition in cultured C6-TK and C6-sr39TK cells 72 hours after ganciclovir (GCV) administration. Cell survival rate (SR) was measured by MTT assay, which showed SR in C6-TK and, especially, the C6-sr39TK group was significantly decreased in a dose-dependent manner as compared with that of the control (*<svg height="11.375" id="M29" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>  versus  C6 group; **<svg height="11.375" id="M30" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>  versus  C6 group; <sup>##</sup><svg height="11.375" id="M31" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>  versus  C6-TK group).</table>

The Scientific World Journal

fig3

Figure 3

Figure 3: Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells 