Prognostic Factors of Peritoneal Metastases from Colorectal Cancer following Cytoreductive Surgery and Perioperative Chemotherapy

Table 3

Results of multivariate analyses and Log-rank test. The Cox multivariate analysis demonstrated CCR-0 (𝑃=0.002): histologic type of differentiated carcinoma (𝑃=0.008), PCI ≤ 10 (𝑃<0.001), and SB-PCIl ≤ 2 (𝑃=0.027) were the independent good prognostic factors.

Variables	Cox hazard model				Log-rank test
	𝑃 value	Relative risk	95% confidential interval	Hazard ratio	𝜒^2	𝑃 value
				Sex
Male versus female	0.303	1.423	0.727–2.724	1.349	2.612	0.106
HIPEC
Done versus not done	0.072	0.555	0.292–1.054	4.446	5.501	0.019
CCR
CCR = 0 versus CCR = 1	0.002	3.47	1.563–7.703	11.707	26.729	<0.001
Age
65 y.o. < versus 65 y.o. ≤	0.141	1.702	0.837–3.461	1.165	3.903	0.005
Lymph node
N0 versus N+	0.562	1.208	0.639–2.280		0.693	0.406
PCI				0.974
PCI = 1 < 0 versus PCI ≥ 11	0.001	3.43	1.925–3.232	8.608	22.564	<0.001
Histology
Differentiated versus Poorly	0.008	2.77	1.306–5.872	5.288	16.95	<0.001
Histologic effect after chemotherapy
EF = 0,1 versus EF = 2,3	0.101	0.413	0.143–1.188	3.501	6.856	0.003
SB-PCI
SB-PCI ≥ 3 versus SB-PCI ≤ 2	0.027	3.356	1.145–9.238	6.182	27.25	<−0.001