Schematic representation of the mechanism of action of the small-molecule inhibitors. Jak: janus kinase; STAT: signal transducing proteins and activator of transcription; STAT-P: phosphorylated STAT (active); PDE 4: phosphodiesterase 4; NF-KB: nuclear factor kappaB; PKC: protein kinases C; DAG: diacylglycerol; cAMP: cyclic adenosine monophosphate; AMP: adenosine monophosphate.
