The Mitigating Effect of Citrullus colocynthis (L.) Fruit Extract against Genotoxicity Induced by Cyclophosphamide in Mice Bone Marrow Cells
Figure 2
Myeloid hypoplasia in femur 24 hours after CP administration 70 mg/kg; (a) compared with myeloid hyperplasia induced by administration of CCT fruits extract at 100 mg/kg; (b) & 200 mg/kg; (c) for 7 consecutive days before CP treatment. CP-induced myelosuppressive effects (a) and CCT led to marked proliferation and hypercellularity of immature myeloid elements after mice were treated with CP and mitigated the bone marrow suppression ((b) and (c)). Note the relative increase in the proportion of myeloid to erythroid precursors after CCT administration (hematoxylin and eosin-stained paraffin sections).
