The Mitigating Effect of Citrullus colocynthis (L.) Fruit Extract against Genotoxicity Induced by Cyclophosphamide in Mice Bone Marrow Cells

Table 2

Levels of MDA, GSH, GSSG, and GSH/GSSG ratio in bone marrow of mice after treatment with CCT (200 mg/kg) and/or CP (70 mg/kg).

Groups (mg/kg)	MDA (µmol/g protein)	GSH (µmol/g protein)	GSSG (µmol/g protein)	GSH/GSSG ratio
Control	0.74±0.17	13.64±4.36	3.38±0.43	4.03±1.07
CP	3.07±0.42^b	3.81±1.47^b	13.38±3.76^b	0.28±0.05^b
CCT	0.71±0.32^c	14.69±5.16^c	2.97±0.35^c	4.94±1.72^c
CCT + CP	1.32±0.24^d	12.37±3.84^e	6.14±3.84^d	2.01±0.63^d

CCT: Citrullus colocynthis; CP: cyclophosphamide; MDA: lipid peroxidation; GSH: reduced glutathione; GSSG: oxidized glutathione.
^aValues are the mean ± standard deviation for each group of 5 mice. ^b𝑃<0.0001 compared to the control. ^cNo significant difference compared to the control group; ^d𝑃<0.001 compared with the CP treated group;^e𝑃<0.0001 compared with the CP treated group.
The data were analyzed with one-way ANOVA and Tukey’s HSD test.