Gene-Gene Interactions in Renin-Angiotensin-Aldosterone System Contributes to End-Stage Renal Disease Susceptibility in a Han Chinese Population

Table 2

Genotype distribution of the RAAS polymorphisms among ESRD patients and control.

Genotypes	Case	Control	Crude OR (95% CI)	𝑃 value	Adjusted OR (95% CI)	𝑃 value
AGT M235T
CC	466	438	1		1
CT	169	182	0.87 (0.68–1.12)	0.280	0.78 (0.59–1.03)	0.075
TT	12	24	0.47 (0.23–0.95)	0.036	0.24 (0.09–0.65)	0.005
T allele	193	230	0.81 (0.65–0.99)	0.044	0.70 (0.55–0.89)	0.003
AGT T174M
CC	508	519	1		1
CT	134	120	1.14 (0.87–1.5)	0.348	1.11 (0.82–1.51)	0.484
TT	5	5	1.02 (0.29–3.55)	0.973	1.19 (0.33–4.25)	0.786
T allele	144	130	1.12 (0.87–1.43)	0.393	1.11 (0.84–1.46)	0.467
AGTR1 A1166C
AA	591	589	1		1
AC	56	55	1.01 (0.69–1.5)	0.941	1.07 (0.7–1.63)	0.761
C allele	56	55	1.01 (0.69–1.48)	0.943	1.06 (0.7–1.61)	0.766
AGTR1 C573T
CC	336	350	1		1
CT	267	240	1.16 (0.92–1.46)	0.209	1.23 (0.96–1.59)	0.105
TT	44	54	0.85 (0.55–1.3)	0.450	0.84 (0.52–1.35)	0.478
T allele	355	348	1.02 (0.86–1.21)	0.812	1.05 (0.87–1.27)	0.633
ACE I/D
II	231	281	1		1
ID	330	297	1.35 (1.07–1.71)	0.012	1.42 (1.09–1.84)	0.009
DD	86	66	1.59 (1.1–2.28)	0.013	1.61 (1.08–2.4)	0.019
D allele	502	429	1.27 (1.08–1.49)	0.004	1.29 (1.08–1.54)	0.005
ACE G2350A
GG	233	274	1		1
GA	299	276	1.27 (1.00–1.62)	0.047	1.35 (1.03–1.76)	0.029
AA	115	94	1.44 (1.04–1.99)	0.028	1.62 (1.14–2.31)	0.008
A allele	529	464	1.23 (1.05–1.44)	0.011	1.31 (1.1–1.56)	0.003
CYP11B2 C-344T
TT	384	340	1		1
TC	205	256	0.71 (0.55–0.92)	0.010	0.70 (0.54–0.91)	0.007
CC	58	48	1.07 (0.69–1.67)	0.761	1.07 (0.69–1.68)	0.756
C allele	321	352	0.88 (0.74–1.05)	0.144	0.87 (0.72–1.06)	0.178

Data were expressed as 𝑛 (%) and have been adjusted by gender, age, BMI, and smoking status.