Balteatide: A Novel Antimicrobial Decapeptide from the Skin Secretion of the Purple-Sided Leaf Frog, Phyllomedusa baltea
Figure 2
(a) Nucleotide and translated open-reading frame amino acid sequence of the sense strand of the cloned cDNA encoding the biosynthetic precursor of balteatide. The putative signal peptide is double-underlined and the mature balteatide sequence is single-underlined. The stop codon is indicated with an asterisk. (b) Domain architecture of the balteatide precursor. Residues 1–22 constitute the putative signal peptide. Residues 23–48 constitute the acidic spacer peptide region typified by classical-KR-(-Lys-Arg-) propeptide convertase processing sites (italicised and in bold typeface). The single copy of mature balteatide (residues 49–58) is underlined and in bold typeface and the C-terminal glycyl (G59) residue that donates the amide moiety is indicated in brackets.
