Development of a Controlled Release of Salicylic Acid Loaded Stearic Acid-Oleic Acid Nanoparticles in Cream for Topical Delivery

Table 1

The mean particle size, polydispersity index, and zeta potential of freshly prepared unloaded and salicylic acid loaded SONs at 25°C.

OA ratio (wt%)	Unloaded SONs			Salicylic acid loaded SONs
	Mean particle size (nm)	Polydispersity index	Zeta potential (mV)	Mean particle size (nm)	Polydispersity index	Zeta potential (mV)
0	194±2	0.19±0.01	−45.9±0.9	271±3	0.25±0.01	−39.4±0.5
10	221±4	0.21±0.02	−47±2	283±8	0.29±0.03	−43±1
20	246±3	0.31±0.03	−45.5±0.5	311±7	0.35±0.02	−45±1
30	255±3	0.37±0.02	−50±1	332±3	0.37±0.03	−43±1
40	229±4	0.37±0.01	−43±1	330±10	0.40±0.02	−44.0±0.8
50	223±4	0.36±0.02	−46±1	280±5	0.38±0.02	−45.2±0.7