Review Article
Gossypol Toxicity from Cottonseed Products
Table 2
Selected experimental studies describing effects of gossypol on male reproduction.
| Animals | Gossypol dose | Effects | Reference |
| Hamsters | 10 mg/kg BW/day | Degeneration of spermatocytes | [48] | Rats | 20 mg/kg BW/day | Degeneration of spermatocytes | [48] | Mice | 40 mg/kg BW/day | No degeneration | [48] | Rats | 25 mg/kg BW/day | Decreased spermatogenesis, Sertoli cell, and seminiferous tubules damage | [49] | Rats | 10 mg/kg BW/day | Tubular degeneration, reduced testosterone concentrations, and involutions of ventral prostate and seminal vesicles | [50] | Rats | 5, 10 and 20 mg/kg BW/day | Decreased sperm count and motility, increased abnormal sperm count, and reduced serum levels of testosterone, LH, and FSH | [47] | Bulls | 16.4 mg/kg BW/day | Reduced sperm production and motility and increased proportion of sperm midpiece abnormalities | [51] | Bulls | 8 mg/kg BW/day | Primary and secondary sperm abnormalities and increased number of sperm with proximal droplets | [52] |
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