Review Article
Gossypol Toxicity from Cottonseed Products
Table 3
Selected experimental studies describing effects of gossypol on female reproduction.
| Animals | Gossypol dose | Effects | Reference |
| Rats | 5 mg/kg BW/day | Longer diestrus | [53] | Rats | 25 mg/kg/day | Lower levels of estradiol-17 | [54] | Rats | 20 mg/kg/day | Irregular and longer estrous cycles, prolonged time for mating, decreased pregnancy rate, and reduced number of viable embryos | [55] | Heifers | ~51 mg/kg BW/day | No interference on cycling, first service conception rate, and ovarian morphology | [56] | Heifers | 5 g of free gossypol/animal/day | Reduced number of ovarian follicles >5 mm | [57] |
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