Design, Synthesis, and In Vitro Kinetics Study of Atenolol Prodrugs for the Use in Aqueous Formulations

Figure 7

First-order hydrolysis plot of atenolol ProD 1 in (a) 1 N HCl, (b) buffer pH 2, and (c) buffer pH 5.

(a) log 𝐶 (mg/mL) versus 𝑡 (hr) 1 N HCL

(b) log 𝐶 (mg/mL) versus 𝑡 (hr) pH 2

(c) log 𝐶 (mg/mL) versus 𝑡 (hr) pH 5