Development, Characterization, and Pharmacodynamic Evaluation of Hydrochlorothiazide Loaded Self-Nanoemulsifying Drug Delivery Systems

Table 1

Solubility studies of HCT in various vehicles.

Vehicle	Function in SNEDDS	Solubility (mg/mL)
Maisine 35-1	Oil	1.97 ± 0.7
Oleic acid	Oil	2.65 ± 0.85
Capmul MCM	Oil	3.43 ± 0.54
Castor oil	Oil	1.68 ± 0.54
Captex 355 EP/NF	Oil	2.26 ± 0.8
Tween 80	Surfactant	161.46 ± 2.54
Cremophor EL	Surfactant	27.19 ± 1.15
Cremophor RH 40	Surfactant	13.15 ± 1.2
Span 20	Surfactant	1.49 ± 0.73
Lauroglycol 90	Surfactant	1.34 ± 0.74
PEG 400	Cosurfactant	357.14 ± 2.94
Propylene glycol	Cosurfactant	53.60 ± 1.05
Transcutol P	Cosurfactant	288.72 ± 2.56