Development, Characterization, and Pharmacodynamic Evaluation of Hydrochlorothiazide Loaded Self-Nanoemulsifying Drug Delivery Systems

Table 4

Characterization of SNEDDS formulations.

Parameters	F1	F2	F3	F4	F5	F6
Drug content (%)	96.78 ± 1.46	98.88 ± 1.53	98.46 ± 1.07	96.88 ± 1.86	102.34 ± 2.41	98.56 ± 1.97
Self-emulsification time (sec)	15 ± 1	18 ± 2	14 ± 1	9 ± 1	8 ± 1	6 ± 2
Precipitation	Stable	Stable	Stable	Stable	Unstable	Unstable
Clarity	Bluish	Bluish	Bluish	Bluish	Turbid	Turbid
Viscosity (cps)
0-time dilution	353	364	326	324	321	302
10-time dilution	1.17	1.16	1.15	1.13	1.12	1.08
100-time dilution	0.888	0.883	0.88	0.863	0.857	0.843
% transmittance	55.73	81.43	71.23	57.41	61.54	56.32
Droplet size (nm)	98.48 ± 10.24	42.84 ± 13.78	151 ± 2.67	158.5 ± 15.32	117.5 ± 3.22	95.84 ± 5.42
Zeta potential (mV)	−10.8 ± 0.11	−15.4 ± 0.09	−11.7 ± 0.23	−12.3 ± 0.15	−12 ± 0.18	−13.6 ± 0.21