Research Article
Development, Characterization, and Pharmacodynamic Evaluation of Hydrochlorothiazide Loaded Self-Nanoemulsifying Drug Delivery Systems
Table 5
Oral administration of pure HCT and optimized SNEDDS formulation F2 compared to control and placebo in Wistar rats.
| | Treatment | HCT | SNEDDS | Control | Placebo |
| | Period 1 | Group 1 | Group 2 | Group 3 | Group 4 |
| | Washout period of 72 hours | | Period 2 | Group 2 | Group 3 | Group 4 | Group 1 |
| | Washout period of 72 hours | | Period 3 | Group 3 | Group 4 | Group 1 | Group 2 |
| | Washout period of 72 hours | | Period 4 | Group 4 | Group 1 | Group 2 | Group 3 |
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