Identification of Levothyroxine Antichagasic Activity through Computer-Aided Drug Repurposing
Figure 7
Effect of levothyroxine on T. cruzi epimastigotes proliferation. To determine the growth rate, 107 cells/mL were seeded in BHT medium and cultured at 28°C with the indicated concentrations of the drug; the control condition was done with 0 μM levothyroxine, 2% DMSO. Parasites were counted daily using a hemocytometer chamber and, once they reached the stationary phase, were rediluted at 107 cells/mL with fresh medium plus the indicated levothyroxine concentration. Results represent the mean ± SD of a representative experiment.
