Research Article

Preparation and Evaluation of Novel In Situ Gels Containing Acyclovir for the Treatment of Oral Herpes Simplex Virus Infections

Table 5

Evaluation data 2 of in situ gel formulation.

FCViscosity (Cp)
Solution stateGel stateSpreadabilityGel strength

Ft198.93 ± 0.401481.33 ± 6.806.63 ± 0.154.67 ± 0.57
Ft2104.88 ± 2.291540.67 ± 15.656.43 ± 0.055.66 ± 0.57
Ft3149.10 ± 2.731505.00 ± 6.005.70 ± 0.1721.33 ± 1.53
Ft4111.61 ±  10.671564.00 ± 7.215.66 ± 0.1223.66 ± 0.57
Ft5158.27 ± 6.681498.67 ± 14.225.26 ± 0.1180.33 ± 0.57
Ft6199.74 ± 0.631594.33 ± 12.894.53 ± 0.1299.66 ± 0.57
Fg1214.41 ± 3.081493.67 ± 5.036.56 ± 0.0510.33 ± 1.52
Fg2220.47 ± 2.161495.67 ± 6.656.30 ± 0.0213.66 ± 1.52
Fg3242.05 ± 2.161533.67 ± 19.505.66 ± 0.2026.33 ± 1.52
Fg4263.60 ± 10.581586.33 ± 5.505.03 ± 0.1565.66 ± 1.15
Fg5242.50 ± 14.901535.33 ± 11.015.23 ± 0.0589.33 ± 0.57
Fg6344.87 ± 5.561621.33 ± 3.214.46 ± 0.05119.3 ± 1.52

The bold data refer to four selected formulations with the best results.