Preparation and Evaluation of Novel In Situ Gels Containing Acyclovir for the Treatment of Oral Herpes Simplex Virus Infections

Table 7

Kinetic analysis of in vitro release data of different formulations.

FC	Zero order		First order		Higuchi model		Hixson crowell model		Korsmeyer peppas model		Best fit model
	𝐾	𝑅^2	𝐾	𝑅^2	𝐾	𝑅^2	𝐾	𝑅^2	𝐾	𝑅^2
Ft4	16.88	0.91	−0.25	0.904	48.69	0.98	−0.52	0.96	0.58	0.98	Higuchi model
Fg4	15.67	0.91	−0.20	0.911	45.21	0.98	−0.45	0.97	0.56	0.98	Peppas model
Ft1	19.33	0.92	−0.31	0.946	39.94	0.93	−0.56	0.93	0.54	0.97	Peppas model
Fg1	20.22	0.94	−0.31	0.937	42.09	0.94	−0.58	0.93	0.50	0.97	Peppas model
MC	17.66	0.94	−0.20	0.928	43.60	0.99	−0.45	0.98	0.72	0.97	Higuchi model