Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells

Table 3

Risk factors for thyroid function.

Disease	Risk factor degree	Timing from HSCT
Hypothyroidism	Radiotherapy to the neck >TBI	Late effect (years from HSCT)
	Single dose of TBI >fractionated TBI
	Allo-HSCT >auto-HSCT
	Chronic GVHD
Subclinical hyperthyroidism	Allo-HSCT	Early effect (within 12 months after HSCT)
Low T3 syndrome	Infections; Nutritional status; Chronic GVHD	Variable up to years after HSCT
	Immunosuppressive therapies
Thyroid carcinoma	Radiochemotherapy >chemotherapy	Late effect (years after HSCT)
	Pediatric age >adult age

Allo: allogeneic; auto: autologous; GVHD: graft-versus-host disease; HSCT: hematopoietic stem cell transplant; TBI: “total body” irradiation.
Symbol (>) means more than.