Review Article
Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells
Table 3
Risk factors for thyroid function.
| Disease | Risk factor degree | Timing from HSCT |
| Hypothyroidism | Radiotherapy to the neck >TBI | Late effect (years from HSCT) | Single dose of TBI >fractionated TBI | Allo-HSCT >auto-HSCT | Chronic GVHD |
| Subclinical hyperthyroidism | Allo-HSCT | Early effect (within 12 months after HSCT) |
| Low T3 syndrome | Infections Nutritional status Chronic GVHD | Variable up to years after HSCT | Immunosuppressive therapies |
| Thyroid carcinoma | Radiochemotherapy >chemotherapy | Late effect (years after HSCT) | Pediatric age >adult age |
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Allo: allogeneic; auto: autologous; GVHD: graft-versus-host disease; HSCT: hematopoietic stem cell transplant; TBI: “total body” irradiation. Symbol (>) means more than.
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