Humanin Rescues Cultured Rat Cortical Neurons from NMDA-Induced Toxicity Not by NMDA Receptor

Figure 3

Effect of humanin on NMDA triggered reduction of cell viability in cortical neurons as measured by MTT cell viability assay. Each bar represents mean ± SEM of five independent observations. Statistical significance is at 𝑃<0.05. 𝐹_(8,64)=2.697 and 𝑃=0.013 according to one-way ANOVA analysis. ∗ represents control versus NMDA group (𝑃=0.032); control versus HN (10 μmol/L), 𝑃=0.421; # represents NMDA group versus NMDA + MK-801 group (𝑃=0.026) or NMDA + HN (Humanin) group. HN (0.01 μmol/L), 𝑃=0.289; HN (0.1 μmol/L), 𝑃=0.036; HN (1 μmol/L), 𝑃=0.024; HN (10 μmol/L), 𝑃=0.012; HN (100 μmol/L), 𝑃=0.021. ∗ and # mean that there is statistical significance between control and treatment groups.