Humanin Rescues Cultured Rat Cortical Neurons from NMDA-Induced Toxicity Not by NMDA Receptor

Figure 4

Effect of humanin on NMDA triggered LDH release in cultured cortical neurons. Each bar represents mean ± SEM of 5–8 independent observations. Statistical significance is at 𝑃<0.05. 𝐹_(8,64)=3.023 and 𝑃=0.006 after one-way ANOVA analysis in SPSS. ∗ represents control versus NMDA group (𝑃=0.028); # represents NMDA group versus NMDA + MK-801 group (𝑃=0.019) or NMDA + HN (Humanin) group. HN (0.01 μmol/L), 𝑃=0.384; HN (0.1 μmol/L), 𝑃=0.301; HN (1 μmol/L), 𝑃=0.039; HN (10 μmol/L), 𝑃=0.036; HN (100 μmol/L), 𝑃=0.040. ∗ and # mean that there is statistical significance between control and treatment groups.