Research Article
RRHGE: A Novel Approach to Classify the Estrogen Receptor Based Breast Cancer Subtypes
Algorithm 1
Pseudocode for the RRHGE algorithm.
Let defines the set of subnetwork based-gene signature, denotes the hub-gene with their | interactors in subnetwork and defines the th training set. | FOR | { | Initialize: | Step 1. Evaluate for all subnetworks and identify the top based subnetwork. | { | FOR each subnetwork from the list of available subnetworks in | { | COMPUTE | } | ENDFOR | IF | THEN | AND remove from the list of available subnetworks in | } | Step 2. Evaluate for all subnetworks and identify the significant hub-genes with their interactors. | { | COMPUTE | FOR each subnetwork from the list of available subnetworks in | { | COMPUTE | { | IF | THEN | } | } | ENDFOR | } | } | RETURN | END |
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