Research Article
Preparation and Characterization of Novel PBAE/PLGA Polymer Blend Microparticles for DNA Vaccine Delivery
Table 1
Characterization of microparticles with respect to mean diameter, zeta potential, mean loading, and encapsulation efficiency.
| | Formulation | Mean diameter (nm) | Zeta potential (mV) | Mean loading (µg/mg) | Encapsulation efficiency (%) |
| | PLGA : A1(50 : 50) | 1034 ± 22.4 | −18.1 ± 1.67 | 1.98 ± 0.12 | 19.88 ± 1.2 | | PLGA : A1(75 : 25) | 997 ± 12.5 | −23.2 ± 1.5 | 1.49 ± 0.15 | 14.96 ± 1.55 | | PLGA : A1(85 : 15) | 1882 ± 23.7 | −17.5 ± 2.4 | 1.32 ± 0.07 | 13.29 ± 0.72 | | PLGA : A2(50 : 50) | 821.2 ± 11.5 | −15 ± 2.83 | 1.42 ± 0.09 | 14.28 ± 0.95 | | PLGA : A2(75 : 25) | 1121 ± 20.1 | −23.1 ± 1.09 | 1.14 ± 0.14 | 11.44 ± 1.48 | | PLGA : A2(85 : 15) | 797.1 ± 9.88 | −36.3 ± 2.47 | 0.98 ± 0.18 | 9.88 ± 1.8 | | PLGA alone (100 : 0) | 612.9 ± 6.39 | −38.1 ± 1.96 | 0.33 ± 0.04 | 3.325 ± 0.43 |
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All the values are represented mean values of three independent experiments.
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