Microwave Assisted Synthesis, Spectral and Antifungal Studies of 2-Phenyl-N,N′-bis(pyridin-4-ylcarbonyl)butanediamide Ligand and Its Metal Complexes

Table 4

% Cytotoxicity by MIC of ligand and its different complexes against three fluconazole-sensitive Candida isolates.

Complexes (µg/mL)	Control	Candida albicans STD 31	Candida glabrata STD 96	Candida kruesi STD 116
		0	0	0
[C22H18N4O4]	MIC	24.7±0.2	20.2±0.8	18.4±1.1
[CoL]Cl2	MIC	48.5±0.1	45.2±0.2	41.5±0.7
[CoL(CH3COO)2]	MIC	41.1±0.4	35.0±0.9	30.7±0.3
[NiL]Cl2	MIC	89.6±0.7	82.1±0.4	88.2±0.6
[NiL(CH3COO)2]	MIC	71.0±0.9	70.8±0.8	67.1±0.9
[CuL]Cl2	MIC	63.0±0.2	59.5±0.5	57.2±0.7
[CuL(CH3COO)2]	MIC	78.2±0.6	74.1±0.7	77.0±0.3

L = [(C₂₂H₁₈N₄O₄)].