NMDA Receptor-Mediated Neuroprotective Effect of the Scutellaria baicalensis Georgi Extract on the Excitotoxic Neuronal Cell Death in Primary Rat Cortical Cell Cultures
Figure 1
High magnification (×400) photomicrographs of cultured embryonic cortical neuronal cells from 14- to 16-day-old rats (in vitro); normal group (untreated). The nuclear membranes are distinct, and the dendrocyte is normal [1]. Glu-[350 μM for 20 min in Mg2+-free EBBS and incubated for 20–24 h at 37°C in MEM supplemented with glucose] treated group, showing cellular swelling; dendrocyte is breaking and the nuclear shape is indistinct [2]. Glutamate-treated group in presence of S. baicalensis (100 μg/mL) extract and maintained as above [3]; note that the cellular shape is generally regular almost like that of untreated group.
