Evaluation on Genotoxicity and Teratogenicity of Aqueous Extract from Cyclocarya paliurus Leaves

Table 3

Effect of C. paliurus leaf aqueous extract on the rate of mouse bone marrow micronucleus. Data are expressed as mean ± SD.

Sex	Dose (g/kg⋅bw)	Number of animals	MNPCEs/PCEs (‰)	NCEs	PCEs/NCEs
Male	10.0	5	1.0±0.7	850	1.181±0.079
	5.0	5	1.6±0.9	871	1.152±0.077
	2.5	5	0.6±0.5	883	1.137±0.083
	Negative	5	0.8±0.8	848	1.185±0.089
	Positive	5	25.0±3.7	1004	0.999±0.055
Female	10.0	5	1.0±1.2	836	1.201±0.086
	5.0	5	1.0±1.0	842	1.193±0.085
	2.5	5	1.4±0.5	874	1.152±0.108
	Negative	5	1.2±0.8	850	1.180±0.074
	Positive	5	26.2±2.6	1010	0.992±0.046

PCE: polychromatic erythrocyte; NCE: normochromatic erythrocyte; MNPCE: micronucleated polychromatic erythrocyte.
Compared to negative controls; 𝑃>0.05. Compared to positive controls; 𝑃<0.01.