Development and Optimization of Polymeric Self-Emulsifying Nanocapsules for Localized Drug Delivery: Design of Experiment Approach

Table 1

Composition of nanocapsule formulation using Box-Behnken design.

Levels	Low		Middle		High
	Coded	Actual (mg)	Coded	Actual (mg)	Coded	Actual (mg)
Independent factors
: conc. of Capryol 90 (oil) (mg)		250	0	500	1	750
: conc. of HPMCAS-HF (polymeric emulsifier) (mg)		100	0	150	1	200
: conc. of Aerosil 200 (adsorbent) (mg)		75	0	100	1	125
Dependent variables
: mean globule size (nm)			Minimize
: encapsulation efficiency (%)			Maximize