Research Article
Formulation and Evaluation of Guggul Lipid Nanovesicles for Transdermal Delivery of Aceclofenac
Table 4
Ex vivo permeation parameters for developed nanovesicle gels (PCG and GLG) with respect to CPG and CF.
| | Formulation code | Flux (μg/cm2/h) | Lag time (hrs) | Permeability coefficient
(cm/h) | Distribution coefficient
(cm2/h × 10−3) | Enhancement ratio |
| | CPG | 0.049 | 4.55 | 4.9 × 10−6 | 0.769 | 1 | | CF | 0.2218 | 3.2 | 2.218 × 10−5 | 1.093 | 4.52 | | PCG-1 | 0.806 | 1.675 | 8.06 × 10−5 | 2.08 | 16.44 | | PCG-2 | 0.6997 | 1.875 | 6.997 × 10−5 | 1.866 | 14.27 | | PCG-3 | 0.4941 | 1.95 | 4.941 × 10−5 | 1.794 | 10.08 | | GLG-1 | 1.4295 | 1.15 | 1.4295 × 10−4 | 3.043 | 29.17 | | GLG-2 | 1.1928 | 1.35 | 1.1928 × 10−4 | 2.59 | 24.34 | | GLG-3 | 0.9047 | 1.55 | 9.047 × 10−5 | 2.258 | 18.46 |
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