Isoprenaline: A Potential Contributor in Sick Sinus Syndrome—Insights from a Mathematical Model of the Rabbit Sinoatrial Node

Figure 4

Effects of Iso on action potential conduction. Action potential profiles in the 2D tissue with the DelF1617 mutant channel under different conditions are shown. (a) Mutant channel alone; (b) [Iso] = 0.5 μM/L; (c) [Ach] = 0.03 μM/L; (d) [Ach] = 0.03 μM/L and 𝐷=0.1; (e) [Ach] = 0.03 μM/L, 𝐷=0.1, and [Iso] = 0.5 μM/L; (f) [Ach] = 0.03 μM/L, 𝐷=0.1, and [Iso] = 2.0 μM/L.

(a)

(b)

(c)

(d)

(e)

(f)