Isoprenaline: A Potential Contributor in Sick Sinus Syndrome—Insights from a Mathematical Model of the Rabbit Sinoatrial Node
Figure 5
(a) Measured pacemaking CL against [Iso] computed from tissue model. Solid circles: controls; solid triangle: DelF1617 mutation; solid inverted triangles: DelF1617 and [Ach] = 0.03 μM/L; open circles: DelF1617, [Ach] = 0.03 μM/L, and ; solid line: without conduction block; dashed line: conduction block occurs in AS. (b) Distribution of CL in controls and patients (i) before and (ii) after Iso injection. Open circles: clinical data of Vallin and Edhag from controls; solid circles: data of Vallin and Edhag from patients.
