Significance of Normalization on Anatomical MRI Measures in Predicting Alzheimer’s Disease

Table 6

Univariate analysis of subcortical volumes using different normalization approaches for AD versus CN*.

Volumes	Raw	ICV	Volumes	Raw	ICV
	𝑃 values			𝑃 values
Right hippocampus	<0.00001	<0.00001	Corpus callosum middle anterior	<0.0001	<0.001
Left inferior lateral ventricle	<0.00001	<0.00001	Right accumbens area	<0.0001	<0.01
Left hippocampus	<0.00001	<0.00001	Corpus callosum posterior	<0.0001	<0.01
Left amygdala	<0.00001	<0.00001	Right thalamus proper	<0.0001	<0.01
Right inferior lateral ventricle	<0.00001	<0.00001	Corpus callosum middle posterior	<0.0001	<0.01
Cortex volume	<0.00001	<0.00001	White matter hypointensities	<0.0001	<0.0001
Left hemisphere cortex volume	<0.00001	<0.00001	Left accumbens area	<0.001	<0.001
Right hemisphere-cortex volume	<0.00001	<0.00001	Cerebral spinal-fluid (CSF)	<0.001	<0.00001
Total gray volume	<0.00001	<0.00001	Right ventral diencephalon	<0.001	ns
3rd ventricle	<0.00001	<0.00001	Left thalamus proper	<0.001	ns
Right amygdala	<0.00001	<0.00001	Non-white matter hypointensities	<0.001	<0.01
Right choroid plexus	<0.00001	<0.00001	Subcortical gray volume	<0.01	<0.05
Right lateral ventricle	<0.00001	<0.00001	Optic chiasm	<0.01	<0.01
Left lateral ventricle	<0.00001	<0.00001	5th ventricle	<0.05	<0.05
Left choroid plexus	<0.00001	<0.00001	Right cerebellum cortex	<0.05	ns
Corpus callosum central	<0.00001	<0.001	Left putamen	<0.05	ns
Corpus callosum anterior	<0.00001	<0.00001	Left cerebellum cortex	ns	<0.05

∗Two-way Student’s 𝑡-test is used for univariate analysis with a significant level of 0.05 for 𝑃 value.