Significance of Normalization on Anatomical MRI Measures in Predicting Alzheimer’s Disease

Table 8

Univariate analysis of cortical thickness for left and right hemispheres*.

Cortical thickness; normalization	Left hemisphere			Right hemisphere
	Raw	ICV	Mean CT	Raw	ICV	Mean CT
Superiortemporal	<0.00001	<0.00001	<0.00001	<0.00001	<0.00001	<0.00001
Entorhinal	<0.00001	<0.00001	<0.00001	<0.00001	<0.00001	<0.00001
Temporalpole	<0.00001	<0.00001	<0.00001	<0.00001	<0.00001	<0.00001
Inferiortemporal	<0.00001	<0.00001	<0.01	<0.00001	<0.0001	<0.01
Middletemporal	<0.00001	<0.00001	<0.05	<0.00001	<0.0001	<0.05
Parahippocampal	<0.00001	<0.00001	<0.01	<0.00001	<0.00001	<0.05
Fusiform	<0.00001	<0.0001	<0.001	<0.00001	<0.001	<0.01
Supramarginal	<0.00001	<0.0001	ns	<0.00001	<0.001	ns
Lateralorbitofrontal	<0.00001	<0.001	ns	<0.00001	<0.01	ns
Parsorbitalis	<0.00001	<0.001	ns	<0.00001	<0.001	ns
Bankssts	<0.00001	<0.0001	ns	<0.00001	<0.001	ns
Superiorfrontal	<0.00001	<0.001	<0.05	<0.00001	<0.001	ns
Parsopercularis	<0.00001	<0.001	ns	<0.00001	<0.01	ns
Insula	<0.00001	<0.001	<0.01	<0.00001	<0.001	<0.01
Rostralanteriorcingulate	<0.00001	<0.01	<0.05	<0.00001	<0.001	<0.001
Isthmuscingulate	<0.00001	<0.01	ns	<0.00001	<0.001	ns
Inferiorparietal	<0.00001	<0.001	<0.05	<0.00001	<0.001	ns
Transversetemporal	<0.00001	<0.001	ns	<0.001	<0.05	ns
Caudalanteriorcingulate	<0.00001	<0.01	ns	<0.00001	<0.01	ns
Parstriangularis	<0.00001	<0.01	<0.05	<0.00001	<0.01	<0.01
Rostralmiddlefrontal	<0.00001	<0.05	<0.0001	<0.00001	<0.05	<0.01
Caudalmiddlefrontal	<0.00001	<0.01	ns	<0.00001	<0.01	ns
Posteriorcingulate	<0.00001	<0.01	ns	<0.00001	<0.01	ns
Precuneus	<0.00001	<0.01	ns	<0.00001	<0.01	ns
Medialorbitofrontal	<0.00001	<0.05	ns	<0.001	ns	ns
Precentral	<0.00001	<0.05	<0.05	<0.0001	<0.05	ns
Frontalpole	<0.0001	<0.05	ns	<0.01	ns	ns
Postcentral	<0.01	ns	<0.00001	<0.01	ns	<0.00001
Superiorparietal	<0.01	ns	<0.00001	<0.01	ns	<0.0001
Lateraloccipital	<0.01	ns	<0.00001	<0.05	ns	<0.00001
Lingual	<0.05	ns	<0.00001	<0.01	ns	<0.00001
Paracentral	<0.05	ns	<0.01	<0.01	ns	<0.01
Pericalcarine	ns	ns	<0.00001	ns	ns	<0.00001
Cuneus	ns	ns	<0.00001	ns	ns	<0.00001

∗Two-way Student’s 𝑡-test is used for univariate analysis with a significant level of 0.05 for 𝑃 value.