Progesterone Increases Apoptosis and Inversely Decreases Autophagy in Human Hepatoma HA22T/VGH Cells Treated with Epirubicin
Figure 2
Apoptosis induction by epirubicin without or with progesterone addition. HA22T/VGH cells were treated with indicated concentrations of epirubicin without or with 30 μM progesterone for 24 h and evaluated by (a) TUNEL staining or (b) caspase-3 activity. Results are expressed as the mean ± standard deviation (S.D.) for three separate experiments. C: untreated cells, E0.03: 0.03 μM epirubicin, E0.1: 0.1 μM epirubicin, E0.3: 0.3 μM epirubicin, and P30: 30 μM progesterone. compared to the untreated controls. # compared to the corresponding epirubicin-treated group.
