Comparison of Protein Acetyltransferase Action of CRTAase with the Prototypes of HAT
Figure 2
Proposed docking conformation of DAMC and acetyl CoA to the binding site (P-domain) of the 3D model structure of human CR. Basic and acidic amino acid residues are shown by blue and red colors, respectively. (a) DAMC (colored in standard atom color) forms H-bond interaction (blue dashed line) with ε-amino group of Lys-207 with its C-2 carbonyl oxygen and C-7 heteroatom oxygen, and carbonyl oxygen forms H-bind with backbone NH of Glu-240. (b) Carbonyl oxygen of acetyl group attached to the thiol group of CoA is hydrogen bonded with backbone NH of Glu-240, and ε-NH3 hydrogen atom of Lys-206 forms hydrogen bond with phosphate oxygen of CoA. The figure was prepared by Pymol software [73].
