Research Article

Optimization (Central Composite Design) and Validation of HPLC Method for Investigation of Emtricitabine Loaded Poly(lactic-co-glycolic acid) Nanoparticles: In Vitro Drug Release and In Vivo Pharmacokinetic Studies

Table 4

Intraday and interday precision and accuracy of emtricitabine in rat plasma ( ).

Concentration (µg/mL)Observed concentration (µg/mL)% precision
% accuracy

Intraday
 0.10.094 ± 0.0022.1294
 0.80.781 ± 0.0313.9697.62
 1.61.592 ± 0.0563.5199.50
 2.01.985 ± 0.1105.5499.25
Interday
 0.10.089 ± 0.0077.8689
 0.80.725 ± 0.0385.2490.62
 1.61.512 ± 0.0895.8894.50
 2.0 1.920 ± 0.1357.0396