Kinetic Evidence for Near Irreversible Nonionic Micellar Entrapment of N-(2′-Methoxyphenyl)phthalimide (1) under the Typical Alkaline Reaction Conditions

Table 2

The values of 𝑘_obs, 𝛿_ap, and 𝐴₀ for alkaline hydrolysis of 1 in the presence of C₁₈E₂₀^a.

[C18E20]T; M	10^4  𝑘obs; s^−1	𝛿ap; M^−1 s^−1	10^2𝐴0	𝑌^bobs	𝑌^ccald	𝐹IT𝟏^d
0.01	41.9±0.3^e	3233±9^e	27.2±0.0^e	7.92	7.89	0
0.012	15.7±0.5	2637±30	28.0±0.1	21.1	9.27	0.17
0.014	11.6±0.4	2459±31	28.6±0.2	28.6	10.6	0.23
0.016	7.11±0.24	1239±15	29.1±0.1	46.7	12.0	0.61
0.018	5.89±0.38	898±19	29.5±0.1	56.4	13.4	0.72
0.02	2.17±0.22	546±26	29.9±0.1	153	14.8	0.83
0.05	f

^a[𝟏₀]=0.1 mM, [NaOH] = 1.0 mM, 𝜆=290 nm, 𝑇=35°C, and the aqueous reaction mixture contained 2% v/v CH₃CN. Footnotes ^b and ^c represent respective footnotes ^b and ^c of Table 1 with replacement of [C₁₂E₂₃] by [C₁₈E₂₀] as well as 𝑘_𝑊=338×10⁻⁴ s⁻¹, 𝜙=0.998, and Ψ=689 M⁻¹ [13]. ^dThe values of 𝐹_IT𝟏 were calculated from (2) with 𝛿_ap^avg=3190 M⁻¹ cm⁻¹. ^eError limits are standard deviations. ^fSpectrophotometrically undetectable reaction within the reaction period of ~260 h, where 𝐴_obs=0.392.