Gastroprotective Activity of Violacein Isolated from Chromobacterium violaceum on Indomethacin-Induced Gastric Lesions in Rats: Investigation of Potential Mechanisms of Action
Figure 9
Effect of L-NAME (NOS inhibitor), NEM (NP-SH antagonist), yohimbine (α 2-receptors antagonist), glibenclamide (K+ATP-channels antagonist), SC560 (COX-1 inhibitor), and Celecoxib (COX-2 inhibitor) on gastroprotective activity of violacein against indomethacin-induced ulcer. Values are mean ± SD (n = 6). compare vehicle + Indo with all the groups; compare Vio (40 mg) + Indo with L-NAME, NEM, YO, GLIB, SC560, or Celecoxib + Vio (40 mg) + Indo. Values in the braces indicate ulcer index inhibition percentage. Indo: indomethacin; Vio: violacein; L-NAME: N-G-nitro-L-arginine methyl ester; NEM: N-ethylmaleimide; YO: yohimbine; GLIB: glibenclamide.
