A Novel One-Pot and One-Step Microwave-Assisted Cyclization-Methylation Reaction of Amino Alcohols and Acetylated Derivatives with Dimethyl Carbonate and TBAC

Table 2

Synthesis of 4-substituted-3-alkyl-1,3-oxazolidin-2-ones under modified conditions.

Entry	Starting material	Reaction conditions; 130°C, 10 min; 200 W	Product	Yield (%)^a,b
1		DMC	Starting material + other unidentified products	—
2		DMC	Only starting material	—
3		DMC, TBAC (0.2 eq)		74
4		DMC, TBAC (0.2 eq)		69
5		DMC, DMF		—
6		DMC, DMF		68
7		DMC, DMF, TEA (1.5 eq)		—
8		DMC, DMF, TEA (1.5 eq)	Unidentified products	—
9		DMC, TEA (1.5 eq)		84
10		DMC, TBAC (0.2 eq)		>99
11		DMC, TEA (1.5 eq)		>99

Isolated yields based on the starting amino alcohol. ^bProducts characterized by ¹H and ¹³C NMR.