A Comparative Analysis of Synonymous Codon Usage Bias Pattern in Human Albumin Superfamily

Table 3

Relative synonymous codon usage in human albumin superfamily members. The value in bold indicates the codons used with high frequency.

Amino acid	Codons	RSCU^1	Number	RSCU^2	Number	RSCU^3	Number	RSCU^4	Number
Phe	UUU	1.43	25	1.06	17	1.30	28	1.16	11
	UUC	0.57	10	0.94	15	0.70	15	0.84	8
Leu	UUA	0.94	10	1.00	10	1.20	11	0.53	5
	UUG	1.13	12	1.10	11	0.87	8	0.63	6
	CUU	1.78	19	0.90	9	1.20	11	1.16	11
	CUC	0.66	7	0.40	4	0.98	9	0.95	9
	CUA	0.38	4	0.90	9	0.65	6	1.05	10
	CUG	1.13	12	1.70	17	1.09	10	1.68	16
Ile	AUU	1.33	4	1.32	15	1.07	10	1.13	3
	AUC	1.33	4	0.71	8	0.75	7	1.13	3
	AUA	0.33	1	0.97	11	1.18	11	0.75	2
Val	GUU	1.12	12	1.47	11	1.44	13	0.89	6
	GUC	0.65	7	0.80	6	0.67	6	1.19	8
	GUA	0.74	8	0.80	6	0.67	6	1.04	7
	GUG	1.49	16	0.93	7	1.22	11	0.89	6
Ser	UCU	0.64	3	1.26	8	2.06	12	1.43	10
	UCC	1.50	7	0.47	3	0.86	5	1.29	9
	UCA	1.29	6	1.58	10	1.03	6	1.71	12
	UCG	0.64	3	0.47	3	0.00	0	0.00	0
Pro	CCU	1.67	10	1.71	9	1.71	12	1.38	9
	CCC	1.00	6	0.76	4	0.71	5	0.92	6
	CCA	1.17	7	1.52	8	1.57	11	1.54	10
	CCG	0.17	1	0.00	0	0.00	0	0.15	1
Thr	ACU	0.97	7	1.78	16	1.18	10	1.25	10
	ACC	1.24	9	0.67	6	0.82	7	1.38	11
	ACA	1.52	11	1.33	12	1.53	13	1.13	9
	ACG	0.28	2	0.22	2	0.47	4	0.25	2
Ala	GCU	1.90	30	1.20	15	1.57	11	1.82	15
	GCC	0.89	14	0.88	11	0.71	5	1.09	9
	GCA	1.08	17	1.68	21	1.29	9	0.85	7
	GCG	0.13	2	0.24	3	0.43	3	0.24	2
Tyr	UAU	1.37	13	1.06	9	1.06	9	1.13	9
	UAC	0.63	6	0.94	8	0.94	8	0.88	7
His	CAU	1.38	11	1.63	13	1.23	8	1.00	4
	CAC	0.63	5	0.38	3	0.77	5	1.00	4
Gln	CAA	1.10	11	1.15	23	1.26	17	1.33	8
	CAG	0.90	9	0.85	17	0.74	10	0.67	4
Asn	AAU	1.29	11	1.00	10	1.03	17	1.33	12
	AAC	0.71	6	1.00	10	0.97	16	0.67	6
Lys	AAA	1.33	40	1.29	33	1.33	28	0.93	20
	AAG	0.67	20	0.71	18	0.67	14	1.07	23
Asp	GAU	1.39	25	1.27	21	1.30	15	1.23	16
	GAC	0.61	11	0.73	12	0.70	8	0.77	10
Glu	GAA	1.23	38	1.24	34	1.36	40	1.26	27
	GAG	0.77	24	0.76	21	0.64	19	0.74	16
Cys	UGU	0.86	15	1.06	18	0.81	13	1.00	14
	UGC	1.14	20	0.94	16	1.19	19	1.00	14
Arg	CGU	0.67	3	0.50	2	0.55	2	0.00	0
	CGC	0.22	1	0.25	1	0.27	1	0.00	0
	CGA	0.67	3	0.50	2	0.55	2	0.92	2
	CGG	0.44	2	0.25	1	0.00	0	0.46	1
Ser	AGU	1.29	6	1.54	9	0.79	5	0.86	6
	AGC	0.64	3	0.51	3	1.42	9	0.71	5
Arg	AGA	2.89	13	2.75	11	3.27	12	2.31	5
	AGG	1.11	5	1.75	7	1.36	5	2.31	5
Gly	GGU	0.92	3	0.75	3	0.62	4	0.29	1
	GGC	0.92	3	0.75	3	0.77	5	1.43	5
	GGA	1.85	6	1.50	6	2.00	13	1.43	5
	GGG	0.31	1	1.50	4	0.62	4	0.86	3

RSCU¹ : RSCU values for ALB; RSCU²: RSCU values for AFP; RSCU³: RSCU values for AFM; RSCU⁴: RSCU values for DBP.