Treatment with Rhizoma Dioscoreae Extract Has Protective Effect on Osteopenia in Ovariectomized Rats

Table 5

Top canonical pathways associated with differentially expressed genes between the RDE-H group and OVX group.

Name	𝑃 value	Number of molecules
Role of osteoblasts, osteoclasts, and chondrocytes in rheumatoid arthritis	6.96𝐸−03	6
Factors promoting cardiogenesis in vertebrates	2.59𝐸−02	3
Role of JAK2 in hormone-like cytokine signaling	2.67𝐸−02	2
Type II diabetes mellitus signaling	5.3𝐸−02	3
Role of macrophages, fibroblasts, and endothelial cells in rheumatoid arthritis	6.16𝐸−02	5

Top canonical pathways for differentially expressed genes were presented. 𝑃 values were calculated by comparing the number of molecules of interest relative to the total number of occurrences of these molecules in all canonical pathways stored in the Ingenuity Pathways knowledge base (Fisher’s exact test with 𝑃 value adjusted using the Benjamin-Hochberg multiple testing correction).