Diuretic Activity of the Aqueous Extract Leaves of Ficus glumosa Del. (Moraceae) in Rats

Table 2

Effects of the aqueous extract of F. glumosa on saluretic and natriuretic activity from 24 h of urine.

Drugs (mg/kg)	Saluretic	Natriuretic	CAI	Saluretic index	Natriuretic index	CAI index
	(Na^+ + Cl^−)	(Na^+/k^+)	Cl/(Na + K)
Control	33.39 ± 3.12	0.93 ± 1.18	0.45 ± 0.67	1.00	1.00	1.00
Extract
225	104.79 ± 4.28***	1.43 ± 1.40*	0.48 ± 0.50*	3.13	1.53	1.07
300	205.51 ± 2.29***	1.92 ± 1.75**	0.64 ± 0.44**	6.15	2.06	1.42
375	304.67 ± 3.34***	3.33 ± 0.80***	0.75 ± 0.42**	9.12	3.58	1.66
Furosemide (2 mg/kg)	187.99 ± 12.67***	2.65 ± 2.45***	0.70 ± 0.49**	5.63	2.85	1.55
Amiloride H. (14 mg/kg)	147.64 ± 4.80***	2.95 ± 2.68***	0.48 ± 0.50**	4.42	3.17	1.07

Values are means ± SEM, , , , and , significant difference compared to the control.
CAI: carbonic anhydrase inhibition;
saluretic index: saluretic activity in test group/saluretic activity in control group;
natriuretic index: natriuretic activity in test group/natriuretic activity in control group;
carbonic anhydrase inhibition index: CAI activity in test group/CAI activity in control group.